PT  - JOURNAL ARTICLE
AU  - Adam T. Hill
AU  - Charles S. Haworth
AU  - Stefano Aliberti
AU  - Alan Barker
AU  - Francesco Blasi
AU  - Wim Boersma
AU  - James D. Chalmers
AU  - Anthony De Soyza
AU  - Katerina Dimakou
AU  - J. Stuart Elborn
AU  - Charles Feldman
AU  - Patrick Flume
AU  - Pieter C. Goeminne
AU  - Michael R. Loebinger
AU  - Rosario Menendez
AU  - Lucy Morgan
AU  - Marlene Murris
AU  - Eva Polverino
AU  - Alexandra Quittner
AU  - Felix C. Ringshausen
AU  - Gregory Tino
AU  - Antoni Torres
AU  - Montserrat Vendrell
AU  - Tobias Welte
AU  - Rob Wilson
AU  - Conroy Wong
AU  - Anne O'Donnell
AU  - Timothy Aksamit
TI  - Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research
AID  - 10.1183/13993003.00051-2017
DP  - 2017 Jun 01
TA  - European Respiratory Journal
PG  - 1700051
VI  - 49
IP  - 6
4099  - http://erj.ersjournals.com/content/49/6/1700051.short
4100  - http://erj.ersjournals.com/content/49/6/1700051.full
SO  - Eur Respir J2017 Jun 01; 49
AB  - There is a need for a clear definition of exacerbations used in clinical trials in patients with bronchiectasis. An expert conference was convened to develop a consensus definition of an exacerbation for use in clinical research.A systematic review of exacerbation definitions used in clinical trials from January 2000 until December 2015 and involving adults with bronchiectasis was conducted. A Delphi process followed by a round-table meeting involving bronchiectasis experts was organised to reach a consensus definition. These experts came from Europe (representing the European Multicentre Bronchiectasis Research Collaboration), North America (representing the US Bronchiectasis Research Registry/COPD Foundation), Australasia and South Africa.The definition was unanimously approved by the working group as: a person with bronchiectasis with a deterioration in three or more of the following key symptoms for at least 48 h: cough; sputum volume and/or consistency; sputum purulence; breathlessness and/or exercise tolerance; fatigue and/or malaise; haemoptysis AND a clinician determines that a change in bronchiectasis treatment is required.The working group proposes the use of this consensus-based definition for bronchiectasis exacerbation in future clinical research involving adults with bronchiectasis.An expert conference has developed a consensus definition of a bronchiectasis exacerbation for clinical research http://ow.ly/oKPY309yTaX