PT  - JOURNAL ARTICLE
AU  - Thomas Gille
AU  - Morgane Didier
AU  - Marouane Boubaya
AU  - Loris Moya
AU  - Angela Sutton
AU  - Zohra Carton
AU  - Fanny Baran-Marszak
AU  - Danielle Sadoun-Danino
AU  - Dominique Israël-Biet
AU  - Vincent Cottin
AU  - Frederic Gagnadoux
AU  - Bruno Crestani
AU  - Marie-Pia d'Ortho
AU  - Pierre-Yves Brillet
AU  - Dominique Valeyre
AU  - Hilario Nunes
AU  - Carole Planès
AU  - collaborators
TI  - Obstructive sleep apnoea and related comorbidities in incident idiopathic pulmonary fibrosis
AID  - 10.1183/13993003.01934-2016
DP  - 2017 Jun 01
TA  - European Respiratory Journal
PG  - 1601934
VI  - 49
IP  - 6
4099  - http://erj.ersjournals.com/content/49/6/1601934.short
4100  - http://erj.ersjournals.com/content/49/6/1601934.full
SO  - Eur Respir J2017 Jun 01; 49
AB  - The objectives of this prospective study were: 1) to determine the prevalence and determinants of obstructive sleep apnoea (OSA) in patients with newly diagnosed idiopathic pulmonary fibrosis (IPF); 2) to determine whether OSA was associated with cardiovascular disease (CVD) as well as increased oxidative stress and levels of IPF biomarkers in the blood.A group of 45 patients with newly diagnosed IPF attended polysomnography. The prevalence of CVD and the severity of coronary artery calcification were investigated by high-resolution computed tomography. The levels of 8-hydroxydeoxyguanosine (8-OH-DG) and various IPF biomarkers in the blood were compared between patients with no or mild OSA (apnoea–hypopnoea index (AHI) <15 events·h−1), with moderate OSA (15 ≤AHI <30 events·h−1) and with severe OSA (AHI ≥30 events·h−1).The prevalence of moderate-to-severe OSA and severe OSA was 62% and 40%, respectively. AHI did not correlate with demographic or physiological data. All patients with severe OSA had a medical history of CVD, versus 41.2% and 40% of those with no or mild OSA, or with moderate OSA, respectively (p<0.0001). Ischaemic heart disease (IHD) and moderate-to-severe coronary artery calcifications were strongly associated with severe OSA. The 8-OH-DG and matrix metalloproteinase-7 serum levels were significantly increased in the severe OSA group.Moderate-to-severe OSA is highly prevalent in incident IPF and severe OSA is strongly associated with the presence of CVD, particularly IHD.Severe sleep apnoea syndrome is associated with cardiovascular disease in incident idiopathic pulmonary fibrosis http://ow.ly/9GTv30bgIOR