TY - JOUR T1 - The effect of 100% oxygen on tidal breathing parameters in preschool children JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01959-2016 VL - 49 IS - 6 SP - 1601959 AU - Rachel E. Foong AU - Alana J. Harper AU - Graham L. Hall AU - Kathryn A. Ramsey Y1 - 2017/06/01 UR - http://erj.ersjournals.com/content/49/6/1601959.abstract N2 - The multiple-breath nitrogen washout (MBN2W) test assesses ventilation distribution by determining the number of functional residual capacity (FRC) lung turnovers required for tidal breathing of 100% oxygen to wash out resident nitrogen from the lungs [1]. In particular, the test has gained significant interest as a tool for monitoring disease progression and prognosis in children with lung disease, with a specific focus on cystic fibrosis (CF) due to its ability to discriminate between health and disease [2]. The use of 100% oxygen has become the preferred choice of inert gas in older children and adults. However, as discussed in the European Respiratory Society/American Thoracic Society consensus statement, there are disadvantages and unknowns as to how patient age, sedation and sleep state may interact with 100% oxygen to alter breathing patterns [3]. It is known that 100% oxygen alters breathing patterns in infants [4, 5] and therefore this approach is not recommended in this age group; however, it is assumed that the effect of 100% oxygen on respiration is diminished beyond infancy [3], with no reported impact of 100% oxygen on breathing parameters in school-aged children [6]. It remains unknown whether hyperoxia affects tidal breathing in young children, as there are no published studies in this age range. This study aimed to determine whether breathing 100% oxygen altered tidal breathing parameters in healthy young children and young children with CF.Multiple breath nitrogen washout does not cause physiologically relevant breathing changes in preschool children http://ow.ly/xv9B30a0c7LWe would like to acknowledge Caroline Gallagher and Jasmine Grdosic (both from the Telethon Kids Institute, Perth, Australia) for assistance with patient recruitment and study measurements. ER -