TY - JOUR T1 - Impact of residual pulmonary obstruction on the long-term outcome of patients with pulmonary embolism JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01980-2016 VL - 49 IS - 5 SP - 1601980 AU - Raffaele Pesavento AU - Lucia Filippi AU - Antonio Palla AU - Adriana Visonà AU - Carlo Bova AU - Marco Marzolo AU - Fernando Porro AU - Sabina Villalta AU - Maurizio Ciammaichella AU - Eugenio Bucherini AU - Giovanni Nante AU - Sandra Battistelli AU - Maria Lorenza Muiesan AU - Giampietro Beltramello AU - Domenico Prisco AU - Franco Casazza AU - Walter Ageno AU - Gualtiero Palareti AU - Roberto Quintavalla AU - Simonetta Monti AU - Nicola Mumoli AU - Nello Zanatta AU - Roberto Cappelli AU - Marco Cattaneo AU - Valentino Moretti AU - Francesco Corà AU - Mario Bazzan AU - Angelo Ghirarduzzi AU - Anna Chiara Frigo AU - Massimo Miniati AU - Paolo Prandoni Y1 - 2017/05/01 UR - http://erj.ersjournals.com/content/49/5/1601980.abstract N2 - The impact of residual pulmonary obstruction on the outcome of patients with pulmonary embolism is uncertain.We recruited 647 consecutive symptomatic patients with a first episode of pulmonary embolism, with or without concomitant deep venous thrombosis. They received conventional anticoagulation, were assessed for residual pulmonary obstruction through perfusion lung scanning after 6 months and then were followed up for up to 3 years. Recurrent venous thromboembolism and chronic thromboembolic pulmonary hypertension were assessed according to widely accepted criteria.Residual pulmonary obstruction was detected in 324 patients (50.1%, 95% CI 46.2–54.0%). Patients with residual pulmonary obstruction were more likely to be older and to have an unprovoked episode. After a 3-year follow-up, recurrent venous thromboembolism and/or chronic thromboembolic pulmonary hypertension developed in 34 out of the 324 patients (10.5%) with residual pulmonary obstruction and in 15 out of the 323 patients (4.6%) without residual pulmonary obstruction, leading to an adjusted hazard ratio of 2.26 (95% CI 1.23–4.16).Residual pulmonary obstruction, as detected with perfusion lung scanning at 6 months after a first episode of pulmonary embolism, is an independent predictor of recurrent venous thromboembolism and/or chronic thromboembolic pulmonary hypertension.Residual pulmonary obstruction after PE is an independent predictive factor of VTE recurrences and/or CTEPH http://ow.ly/XK49308SDTd ER -