PT  - JOURNAL ARTICLE
AU  - Vladimir Koblizek
AU  - Branislava Milenkovic
AU  - Adam Barczyk
AU  - Ruzena Tkacova
AU  - Attila Somfay
AU  - Kirill Zykov
AU  - Neven Tudoric
AU  - Kosta Kostov
AU  - Zuzana Zbozinkova
AU  - Jan Svancara
AU  - Jurij Sorli
AU  - Alvils Krams
AU  - Marc Miravitlles
AU  - Arschang Valipour
TI  - Phenotypes of COPD patients with a smoking history in Central and Eastern Europe: the POPE Study
AID  - 10.1183/13993003.01446-2016
DP  - 2017 May 01
TA  - European Respiratory Journal
PG  - 1601446
VI  - 49
IP  - 5
4099  - http://erj.ersjournals.com/content/49/5/1601446.short
4100  - http://erj.ersjournals.com/content/49/5/1601446.full
SO  - Eur Respir J2017 May 01; 49
AB  - Chronic obstructive pulmonary disease (COPD) represents a major health problem in Central and Eastern European (CEE) countries; however, there are no data regarding clinical phenotypes of these patients in this region.Participation in the Phenotypes of COPD in Central and Eastern Europe (POPE) study was offered to stable patients with COPD in a real-life setting. The primary aim of this study was to assess the prevalence of phenotypes according to predefined criteria. Secondary aims included analysis of differences in symptom load, comorbidities and pharmacological treatment.3362 patients with COPD were recruited in 10 CEE countries. 63% of the population were nonexacerbators, 20.4% frequent exacerbators with chronic bronchitis, 9.5% frequent exacerbators without chronic bronchitis and 6.9% were classified as asthma–COPD overlap. Differences in the distribution of phenotypes between countries were observed, with the highest heterogeneity observed in the nonexacerbator cohort and the lowest heterogeneity observed in the asthma–COPD cohort. There were statistically significant differences in symptom load, lung function, comorbidities and treatment between these phenotypes.The majority of patients with stable COPD in CEE are nonexacerbators; however, there are distinct differences in surrogates of disease severity and therapy between predefined COPD phenotypes.Distinct phenotypes of COPD in Central and Eastern Europe have differences in symptoms, comorbidities and treatment http://ow.ly/oMZI307ndr5