PT  - JOURNAL ARTICLE
AU  - Qi Yan
AU  - John Brehm
AU  - Maria Pino-Yanes
AU  - Erick Forno
AU  - Jerome Lin
AU  - Sam S. Oh
AU  - Edna Acosta-Perez
AU  - Cathy C. Laurie
AU  - Michelle M. Cloutier
AU  - Benjamin A. Raby
AU  - Adrienne M. Stilp
AU  - Tamar Sofer
AU  - Donglei Hu
AU  - Scott Huntsman
AU  - Celeste S. Eng
AU  - Matthew P. Conomos
AU  - Deepa Rastogi
AU  - Kenneth Rice
AU  - Glorisa Canino
AU  - Wei Chen
AU  - R. Graham Barr
AU  - Esteban G. Burchard
AU  - Juan C. Celedón
TI  - A meta-analysis of genome-wide association studies of asthma in Puerto Ricans
AID  - 10.1183/13993003.01505-2016
DP  - 2017 May 01
TA  - European Respiratory Journal
PG  - 1601505
VI  - 49
IP  - 5
4099  - http://erj.ersjournals.com/content/49/5/1601505.short
4100  - http://erj.ersjournals.com/content/49/5/1601505.full
SO  - Eur Respir J2017 May 01; 49
AB  - Puerto Ricans are disproportionately affected with asthma in the USA. In this study, we aim to identify genetic variants that confer susceptibility to asthma in Puerto Ricans.We conducted a meta-analysis of genome-wide association studies (GWAS) of asthma in Puerto Ricans, including participants from: the Genetics of Asthma in Latino Americans (GALA) I-II, the Hartford–Puerto Rico Study and the Hispanic Community Health Study. Moreover, we examined whether susceptibility loci identified in previous meta-analyses of GWAS are associated with asthma in Puerto Ricans.The only locus to achieve genome-wide significance was chromosome 17q21, as evidenced by our top single nucleotide polymorphism (SNP), rs907092 (OR 0.71, p=1.2×10−12) at IKZF3. Similar to results in non-Puerto Ricans, SNPs in genes in the same linkage disequilibrium block as IKZF3 (e.g. ZPBP2, ORMDL3 and GSDMB) were significantly associated with asthma in Puerto Ricans. With regard to results from a meta-analysis in Europeans, we replicated findings for rs2305480 at GSDMB, but not for SNPs in any other genes. On the other hand, we replicated results from a meta-analysis of North American populations for SNPs at IL1RL1, TSLP and GSDMB but not for IL33.Our findings suggest that common variants on chromosome 17q21 have the greatest effects on asthma in Puerto Ricans.Common allelic variants on chromosome 17q21 have the greatest effects on asthma in Puerto Ricans, a high-risk group http://ow.ly/OtZq3084XV1