TY - JOUR T1 - Sleep apnoea, insulin resistance and diabetes: the first step is in the fat JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00179-2017 VL - 49 IS - 4 SP - 1700179 AU - Isaac Almendros AU - Francisco García-Río Y1 - 2017/04/01 UR - http://erj.ersjournals.com/content/49/4/1700179.abstract N2 - Over the last few years, the relationship between obstructive sleep apnoea (OSA) and various metabolic disorders, especially type 2 diabetes (T2D), has emerged strongly. This circumstance is particularly relevant in terms of public healthcare, considering that 415 million people were affected by diabetes in 2015, with an expected prevalence of 642 million by 2040. To this, we must also add another 318 million individuals with features indicating future risk for developing T2D, including fasting hyperglycaemia, impaired glucose tolerance and insulin resistance [1]. The healthcare expenditure for diabetes in Europe was about €75 billion in 2011, which is projected to increase to €90 billion by 2030 [1, 2].Intermittent hypoxia's effect on adipose tissue induces insulin resistance: a first step in the OSA–diabetes link http://ow.ly/UzIm309kEMi ER -