TY - JOUR T1 - Overnight urinary isoprostanes as a marker of oxidative stress in obstructive sleep apnoea JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01787-2016 VL - 49 IS - 2 SP - 1601787 AU - Chris D. Turnbull AU - Ioannis Akoumianakis AU - Charalambos Antoniades AU - John R. Stradling Y1 - 2017/02/01 UR - http://erj.ersjournals.com/content/49/2/1601787.abstract N2 - Oxidative stress is thought to be of importance in the development of cardiovascular disease in obstructive sleep apnoea (OSA). However, our recent study [1] using data from two centres showed that markers of oxidative stress were not increased by the return of OSA caused by continuous positive airways pressure (CPAP) withdrawal for 2 weeks. Unexpectedly, we found decreased levels of urinary isoprostanes in early morning urine specimens and this, combined with increased levels of blood superoxide dismutase, raised the possibility that oxidative stress might be decreased by OSA.Urinary isoprostanes, a key biomarker of oxidative stress, are not increased by OSA during CPAP withdrawal http://ow.ly/grU8305ZX1s ER -