RT Journal Article
SR Electronic
T1 Association between sleep apnoea and pulmonary hypertension in Kyrgyz highlanders
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1601530
DO 10.1183/13993003.01530-2016
VO 49
IS 2
A1 Tsogyal D. Latshang
A1 Michael Furian
A1 Sayaka S. Aeschbacher
A1 Silvia Ulrich
A1 Batyr Osmonov
A1 Erkin M. Mirrakhimov
A1 Jainagul Isakova
A1 Almaz A. Aldashev
A1 Talant M. Sooronbaev
A1 Konrad E. Bloch
YR 2017
UL http://erj.ersjournals.com/content/49/2/1601530.abstract
AB This case–control study evaluates a possible association between high altitude pulmonary hypertension (HAPH) and sleep apnoea in people living at high altitude.Ninety highlanders living at altitudes >2500 m without excessive erythrocytosis and with normal spirometry were studied at 3250 m (Aksay, Kyrgyzstan); 34 healthy lowlanders living below 800 m were studied at 760 m (Bishkek, Kyrgyzstan). Echocardiography, polysomnography and other outcomes were assessed. Thirty-six highlanders with elevated mean pulmonary artery pressure (mPAP) >30 mmHg (31–42 mmHg by echocardiography) were designated as HAPH+. Their data were compared to that of 54 healthy highlanders (HH, mPAP 13–28 mmHg) and 34 healthy lowlanders (LL, mPAP 8–24 mmHg).The HAPH+ group (median age 52 years (interquartile range 47–59) had a higher apnoea–hypopnoea index (AHI) of 33.8 events·h−1 (26.9–54.6) and spent a greater percentage of the night-time with an oxygen saturation <90% (T<90; 78% (61–89)) than the HH group (median age 39 years (32–48), AHI 9.0 events·h−1 (3.6–16), T<90 33% (10–69)) and the LL group (median age 40 years (30–47), AHI 4.3 events·h−1 (1.4–12.6), T<90 0% (0–0)); p<0.007 for AHI and T<90, respectively, in HAPH+ versus others. In highlanders, multivariable regression analysis confirmed an independent association between mPAP and both AHI and T<90, when controlled for age, gender and body mass index.Pulmonary hypertension in highlanders is associated with sleep apnoea and hypoxaemia even when adjusted for age, gender and body mass index, suggesting pathophysiologic interactions between pulmonary haemodynamics and sleep apnoea.PH in highland residents is associated with sleep apnoea, suggesting a pathophysiologic interaction http://ow.ly/CQ1k305CQeq