TY - JOUR T1 - An association of particulate air pollution and traffic exposure with mortality after lung transplantation in Europe JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00484-2016 VL - 49 IS - 1 SP - 1600484 AU - David Ruttens AU - Stijn E. Verleden AU - Esmée M. Bijnens AU - Ellen Winckelmans AU - Jens Gottlieb AU - Gregor Warnecke AU - Federica Meloni AU - Monica Morosini AU - Wim Van Der Bij AU - Erik A. Verschuuren AU - Urte Sommerwerck AU - Gerhard Weinreich AU - Markus Kamler AU - Antonio Roman AU - Susana Gomez-Olles AU - Cristina Berastegui AU - Christian Benden AU - Are Martin Holm AU - Martin Iversen AU - Hans Henrik Schultz AU - Bart Luijk AU - Erik-Jan Oudijk AU - Johanna M. Kwakkel-van Erp AU - Peter Jaksch AU - Walter Klepetko AU - Nikolaus Kneidinger AU - Claus Neurohr AU - Paul Corris AU - Andrew J. Fisher AU - James Lordan AU - Gerard Meachery AU - Davide Piloni AU - Elly Vandermeulen AU - Hannelore Bellon AU - Barbara Hoffmann AU - Danielle Vienneau AU - Gerard Hoek AU - Kees de Hoogh AU - Benoit Nemery AU - Geert M. Verleden AU - Robin Vos AU - Tim S. Nawrot AU - Bart M. Vanaudenaerde Y1 - 2017/01/01 UR - http://erj.ersjournals.com/content/49/1/1600484.abstract N2 - Air pollution from road traffic is a serious health risk, especially for susceptible individuals. Single-centre studies showed an association with chronic lung allograft dysfunction (CLAD) and survival after lung transplantation, but there are no large studies.13 lung transplant centres in 10 European countries created a cohort of 5707 patients. For each patient, we quantified residential particulate matter with aerodynamic diameter ≤10 µm (PM10) by land use regression models, and the traffic exposure by quantifying total road length within buffer zones around the home addresses of patients and distance to a major road or freeway.After correction for macrolide use, we found associations between air pollution variables and CLAD/mortality. Given the important interaction with macrolides, we stratified according to macrolide use. No associations were observed in 2151 patients taking macrolides. However, in 3556 patients not taking macrolides, mortality was associated with PM10 (hazard ratio 1.081, 95% CI 1.000–1.167); similarly, CLAD and mortality were associated with road lengths in buffers of 200–1000 and 100–500 m, respectively (hazard ratio 1.085– 1.130). Sensitivity analyses for various possible confounders confirmed the robustness of these associations.Long-term residential air pollution and traffic exposure were associated with CLAD and survival after lung transplantation, but only in patients not taking macrolides.Long-term residential air pollution/traffic exposure associated with CLAD and survival after lung transplantation http://ow.ly/Izxj304uA5k ER -