TY - JOUR T1 - Chronic effects of air pollution on lung function after lung transplantation in the Systems prediction of Chronic Lung Allograft Dysfunction (SysCLAD) study JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00206-2016 VL - 49 IS - 1 SP - 1600206 AU - Meriem Benmerad AU - Rémy Slama AU - Karine Botturi AU - Johanna Claustre AU - Antoine Roux AU - Edouard Sage AU - Martine Reynaud-Gaubert AU - Carine Gomez AU - Romain Kessler AU - Olivier Brugière AU - Jean-François Mornex AU - Sacha Mussot AU - Marcel Dahan AU - Véronique Boussaud AU - Isabelle Danner-Boucher AU - Claire Dromer AU - Christiane Knoop AU - Annick Auffray AU - Johanna Lepeule AU - Laure Malherbe AU - Frederik Meleux AU - Laurent Nicod AU - Antoine Magnan AU - Christophe Pison AU - Valérie Siroux Y1 - 2017/01/01 UR - http://erj.ersjournals.com/content/49/1/1600206.abstract N2 - An irreversible loss in lung function limits the long-term success in lung transplantation. We evaluated the role of chronic exposure to ambient air pollution on lung function levels in lung transplant recipients (LTRs).The lung function of 520 LTRs from the Cohort in Lung Transplantation (COLT) study was measured every 6 months. The levels of air pollutants (nitrogen dioxide (NO2), particulate matter with an aerodynamic cut-off diameter of x µm (PMx) and ozone (O3)) at the patients' home address were averaged in the 12 months before each spirometry test. The effects of air pollutants on forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) in % predicted were estimated using mixed linear regressions. We assessed the effect modification of macrolide antibiotics in this relationship.Increased 12-month levels of pollutants were associated with lower levels of FVC % pred (−2.56%, 95% CI −3.86–−1.25 for 5 µg·m−3 of PM10; −0.75%, 95% CI −1.38–−0.12 for 2 µg·m−3 of PM2.5 and −2.58%, 95% CI −4.63–−0.53 for 10 µg·m−3 of NO2). In patients not taking macrolides, the deleterious association between PM and FVC tended to be stronger and PM10 was associated with lower FEV1.Our study suggests a deleterious effect of chronic exposure to air pollutants on lung function levels in LTRs, which might be modified with macrolides.Chronic exposure to air pollutants is associated with reduced lung function in lung transplant recipients http://ow.ly/gH8e304Qac4 ER -