RT Journal Article
SR Electronic
T1 Laboratory diagnosis of pneumonia in the molecular age
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 1764
OP 1778
DO 10.1183/13993003.01144-2016
VO 48
IS 6
A1 Antoni Torres
A1 Nelson Lee
A1 Catia Cilloniz
A1 Jordi Vila
A1 Menno Van der Eerden
YR 2016
UL http://erj.ersjournals.com/content/48/6/1764.abstract
AB Pneumonia remains a worldwide health problem with a high rate of morbidity and mortality. Identification of microbial pathogens which cause pneumonia is an important area for optimum clinical management of pneumonia patients and is a big challenge for conventional microbiological methods. The development and implementation of molecular diagnostic tests for pneumonia has been a major advance in the microbiological diagnosis of respiratory pathogens in recent years. However, with new knowledge regarding the microbiome, together with the recognition that the lungs are a dynamic microbiological ecosystem, our current concept of pneumonia is not totally realistic as this new concept of pneumonia involves a dysbiosis or alteration of the lung microbiome. A new challenge for microbiologists and clinicians has therefore arisen. There is much to learn regarding the information provided by this new diagnostic technology, which will lead to improvements in the time to antibiotic therapy, targeted antibiotic selection and more effective de-escalation and improved stewardship for pneumonia patients. This article provides an overview of current methods of laboratory diagnosis of pneumonia in the molecular age.Integration of novel diagnostics for rapid microbial identification will impact laboratory diagnosis of pneumonia http://ow.ly/2aJh304NuCn