PT  - JOURNAL ARTICLE
AU  - Pinto, Tiago
AU  - Santos, Vanessa
AU  - Drummond, Marta
AU  - Gonçalves, Miguel R.
TI  - Short-term effects, long-term compliance and admissions in patients with obesity hypoventilation syndrome under noninvasive mechanical ventilation
AID  - 10.1183/13993003.congress-2016.PA3054
DP  - 2016 Sep 01
TA  - European Respiratory Journal
PG  - PA3054
VI  - 48
IP  - suppl 60
4099  - http://erj.ersjournals.com/content/48/suppl_60/PA3054.short
4100  - http://erj.ersjournals.com/content/48/suppl_60/PA3054.full
SO  - Eur Respir J2016 Sep 01; 48
AB  - Background: Noninvasive ventilation (NIV) is an established treatment for patients with obesity hypoventilations syndrome (OHS), however short-term physiologic effects, compliance data and admissions remains lacking.Objective: To describe and analyze the short-term physiologic effects of a NIV ambulatory adaptation, a compliance follow-up and admissions, in stable patients with OHS.Methods: One hundred and twenty nine patients (91 females), with median(IQR) age of 68(59-77), BMI of 40(36-44), AHI of 35(19-64) witch 54%>30, and PaCO2 of 50(47-53)were submitted to NIV ambulatory adaptation. Ventilator settings were titrated gradually for the patient comfort with IPAP of 21(18-24), EPAP of 9(8-11), Respiratory Rate (RR) of 14(14-15) and in 120 patients (93%) with a oro-nasal interface. Pulse oximetry (SpO2), transcutaneous CO2 (TcCO2), RR, Tidal Volume (Vt) were registered before and after the NIV trial. A 6 months compliance follow-up was performed.Results: All patients had a significant improvement in RR [22(20-24) vs 15(15-17) bpm, p<0,001], SpO2 [91(88-94) vs 96(94-97)%, p<0,001], TcCO2 [50(46-55) vs 43(37-46)mmHg, p<0,001]. Regarding the NIV compliance the average daily use (hours/day) was 6:45(5:23-8:07) and the % of days with NIV use above 4 hours was 96(73-100)%. Despite the 6 months follow-up, patients remain under NIV for 23(12-34)months. Concerning the respiratory admissions during the study, 66% had 0, 18% had 1 and 11% had 2.Conclusions: This study confirms that NIV ambulatory adaptation improves short-term physiologic parameters, the long-term compliance and low rate of respiratory admissions in OHS patients.