RT Journal Article
SR Electronic
T1 Exhaled surfactant protein A and albumin in a healthy Swedish population
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA1069
DO 10.1183/13993003.congress-2016.PA1069
VO 48
IS suppl 60
A1 Ekaterina Mirgorodskaya
A1 Per Larsson
A1 Hatice Koca
A1 Jeong-Lim Kim
A1 Björn Bake
A1 Evert Ljungström
A1 Anna-Carin Olin
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA1069.abstract
AB Surfactant protein A (SP-A) is the major lung surfactant protein important for surfactant function and host-defense. Exhaled SP-A was suggested as a marker of airway inflammation in COPD patients1. However, no data on expected normal values of exhaled SP-A is available.The aim of the present study was to estimate normal values for exhaled SP-A and albumin in a healthy Swedish population and investigate relationships between the observed protein concentrations and age, gender, body size as well as spirometry data.Healthy individuals were selected from the participants of ECRHS III, examined at the Gothenburg center (N=154, age:40-66). In addition to the standard evaluation, all participants provided exhaled breath samples collected using the PExA method2. Exhaled proteins were measured by ELISA and reported as mass percent of exhaled particles (%, w/w). Log transformed data were evaluated by multiple linear regression analysis.The median exhaled SP-A was 3.22% (Q1=2.59, Q3=4.07). No associations were observed between SP-A and the evaluated variables. The median exhaled albumin was 6.41% (Q1=5.30, Q3=7.91). Albumin was associated to age with 0.8% increase per age year (p<0.05) and to particle concentration per exhalation with 0.9% increase per ng increase in particle mass (p<0.05).SP-A is not associated with age, gender and body size in a healthy population. This is attractive for a candidate marker as no corrections for these variables is required. For albumin, the age of the subject has to be taken into account when evaluating patient data.1. Larstad M, Plos One 2015, 10(12)2. Almstrand AC, Anal Chem 2009, 81:662.