PT - JOURNAL ARTICLE AU - Ekaterina Mirgorodskaya AU - Per Larsson AU - Hatice Koca AU - Jeong-Lim Kim AU - Björn Bake AU - Evert Ljungström AU - Anna-Carin Olin TI - Exhaled surfactant protein A and albumin in a healthy Swedish population AID - 10.1183/13993003.congress-2016.PA1069 DP - 2016 Sep 01 TA - European Respiratory Journal PG - PA1069 VI - 48 IP - suppl 60 4099 - http://erj.ersjournals.com/content/48/suppl_60/PA1069.short 4100 - http://erj.ersjournals.com/content/48/suppl_60/PA1069.full SO - Eur Respir J2016 Sep 01; 48 AB - Surfactant protein A (SP-A) is the major lung surfactant protein important for surfactant function and host-defense. Exhaled SP-A was suggested as a marker of airway inflammation in COPD patients1. However, no data on expected normal values of exhaled SP-A is available.The aim of the present study was to estimate normal values for exhaled SP-A and albumin in a healthy Swedish population and investigate relationships between the observed protein concentrations and age, gender, body size as well as spirometry data.Healthy individuals were selected from the participants of ECRHS III, examined at the Gothenburg center (N=154, age:40-66). In addition to the standard evaluation, all participants provided exhaled breath samples collected using the PExA method2. Exhaled proteins were measured by ELISA and reported as mass percent of exhaled particles (%, w/w). Log transformed data were evaluated by multiple linear regression analysis.The median exhaled SP-A was 3.22% (Q1=2.59, Q3=4.07). No associations were observed between SP-A and the evaluated variables. The median exhaled albumin was 6.41% (Q1=5.30, Q3=7.91). Albumin was associated to age with 0.8% increase per age year (p<0.05) and to particle concentration per exhalation with 0.9% increase per ng increase in particle mass (p<0.05).SP-A is not associated with age, gender and body size in a healthy population. This is attractive for a candidate marker as no corrections for these variables is required. For albumin, the age of the subject has to be taken into account when evaluating patient data.1. Larstad M, Plos One 2015, 10(12)2. Almstrand AC, Anal Chem 2009, 81:662.