%0 Journal Article %A Tetsuo Miyagawa %A Tomomi Ichiba %T Effects of oscillatory positive expiratory pressure on mucus draining, rheological property and lung mechanics: Comparison of Acapella® versus Vibralung® %D 2016 %R 10.1183/13993003.congress-2016.PA3750 %J European Respiratory Journal %P PA3750 %V 48 %N suppl 60 %X Background: Oscillatory positive expiratory pressure (oPEP) devices are used to improve pulmonary function and airway clearance.The purpose of this study was to compare movement distance of different viscoelastic mucus stimulants (MS) on different lung mechanics in two oPEP devices.Methods: oPEP equipment (Acapella® and Vibralung®) were compared the movement distance of MS in tube length 1m internal diameter 1cm with varying compliance and resistance using a TTL model lung. MS were prepared using thickener 1% (purulent sputum of chronic bronchitis) and 4% (plug mucus of asthma attack). We measured migration length of MS by applying Bellavista® mechanical ventilator drove 1 minute, PCV mode, inspiratory pressure 10cmH2O, PEEP 5cmH2O, respiratory rate 12/min. Acapella® blue and Acapella® green were set highest and lowest resistance each. Vibralung® was set random noise, low, medium and high frequency each.Results: The migration length of MS in Vibralung® were longer than Acapella® blue and Acapella® green highest resistance on different viscoelastic MS and lung mechanics (p<0.05). There is no difference of movement distance of MS in each setting of Vibralung®. The movement distance of MS1% was longer than MS4% in Acapella® and Vibralung® (p<0.05). However, the difference of migration length of different viscoelastic MS in Vibralung® was smaller compared with Acapella®.Conclusions: Acapella® needs voluntary expiratory flow to oscillate. However, Vibralung® can oscillate without voluntary breath. Vibralung® is easy to use for patients with lower pulmonary function, worse lung mechanics and higher viscoelastic secretions. %U