PT - JOURNAL ARTICLE AU - Narendra Umashankar AU - K.C. Agarwal AU - Gopal Purohit AU - C.R. Choudhary AU - Sunil Vyas AU - Deepak Ug AU - Srikant Agarwal AU - Isha Garg TI - Alternate overlap syndrome: Association of asthma with obstructive sleep apnea AID - 10.1183/13993003.congress-2016.PA4159 DP - 2016 Sep 01 TA - European Respiratory Journal PG - PA4159 VI - 48 IP - suppl 60 4099 - http://erj.ersjournals.com/content/48/suppl_60/PA4159.short 4100 - http://erj.ersjournals.com/content/48/suppl_60/PA4159.full SO - Eur Respir J2016 Sep 01; 48 AB - Introduction: Obstructive sleep apnea (OSA) and asthma are common disorders with prevalence of 8% and 2% respectively in India. Both share several risk factors and comorbidities in common. Multiple factors have been postulated for this coexistence, which is referred to as alternate overlap syndrome.Aims and Objectives: To assess the prevalence of OSA in asthmatics and to assess the factors responsible for OSA in asthmaMethods: 50 patients who met the study criteria were enrolled. Demographic and clinical data including comorbidities were collected. Spirometry was done in all patients and subjected to type 1 polysomnography. Level of asthma control was assessed using GINA 2014 guidelines.Results: OSA was present in 17 patients (34%). 9 out of 18 females had OSA as compared to 8 out of 32 males. Prevalence of OSA in well, partially and un-controlled asthma was 0%, 17.4% and 68.4% respectively. OSA was significantly associated with increased age (0.001), high BMI (p<0.001), longer duration of illness (p=0.001), exacerbations (p=0.005), high dose inhalational steroids (p<0.001), rhinitis (p=0.04), FEV1% (p=0.001) and poor control of asthma (p<0.001).Conclusion: OSA is more common in asthma when compared to general population. Poor control of asthma and disease progression are the important factors that contribute in the development of OSA. Patients having asthma especially poorly controlled asthma may be considered for evaluation for sleep related breathing disorders, if present, could be managed in order to achieve good asthma control.