TY - JOUR T1 - The characteristic of chronic renal dysfunction in patients with chronic obstructive pulmonary disease JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA4627 VL - 48 IS - suppl 60 SP - PA4627 AU - Anna Dudnikova AU - Elena Bolotova Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA4627.abstract N2 - Introduction: At present it is considered that systemic effects in chronic obstructive pulmonary disease (COPD) is represented by cardiovascular diseases, osteoporosis. Peculiarities of development of renal dysfunction remains poorly understood in this disease.Aim: To investigate the frequency of chronic kidney disease (CKD) in patients with COPD.Materials and methods: We have examined 200 patients with COPD, patients were divided into 4 groups: A, B, C, D, according to the classification of GOLD 2014. They were carried out the calculation of estimated glomerular filtration rate (eGFR) by creatinine (eGFRcr) by using the formula CKD-EPI and cystatin C (eGFRcys) and urine albumin-creatinine ratio (ACR).The diagnosis of CKD was defined when the decrease in eGFR<60 ml/min/1,73m2, the value of ACR>3 mg/mmol (KDIGO 2013).Results: Creatinine levels did not significantly differ by group (75,9±6,8 and 82,4±4,3 µmol/l in A and B vs 72,6±4,5 and 70,4±3,9 µmol/l in C and D, p<0,05). CKD was identified in 44,5% of patients according to eGFRcr and the frequency 56% according to eGFRcys. The frequency of elevated ACR was 22,5%. CKD was significantly more frequently observed in groups with frequent exacerbations in groups C and Dand practically did not depend on the severity of symptoms (15% and 21% in C and D vs 11% and 9% in A and B, χ2=11,5; p<0.05).Conclusions: The high prevalence of CKD in patients with COPD and the relationship of renal dysfunction and exacerbation frequency have been revealed. The calculation of GFR by cystatin C is more exact method in patients with COPD. ER -