RT Journal Article
SR Electronic
T1 COPD patients admitted in ICU for acute exacerbation: Impact of exacerbation factors on prognosis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA2139
DO 10.1183/13993003.congress-2016.PA2139
VO 48
IS suppl 60
A1 Amani Ben Mansour
A1 Takoua Merhabene
A1 Amira Jamoussi
A1 Jalila Ben Khlil
A1 Mohamed Besbes
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA2139.abstract
AB Background: Acute exacerbation of patients with chronic obstructive pulmonary disease(COPD)may complicate the evolution of the disease.The aim was to study characteristics and outcomes of patients admitted in ICU for acute exacerbation of COPD and to determine the impact of the exacerbation factor on prognosis.Methods: Retrospective cohort study from January2013toMarch2014. We described epidemiology,etiology,treatment and outcomes of COPD patients. Exacerbation factors were classified into3groups:G1. Infectious causes: pneumonia or acute bronchitis.G2. Non- infectious causes: pulmonary embolism, pneumothorax or acute heart failure.G3. No causes found.Results: 132 patients were included. The median age was 64 ± 10 years and sex ratio 5.3. 59,1% of patients had chronic pulmonary heart. The use of mechanical ventilation at admission was required in 117 patients (88.6%).EtiologyComplicationsMortalityInfectious causes n(%)80(60,6)28(62,2)20(45,4)Pneumonia n(%)37(28)19(51,4)*15(40,5)Acute bronchitis n(%)43(32,6)9(20,9)*5(11,6)*Non infectious causes n(%)28(21,2)8(28,5)9(32,1)No causes n(%)24(18,2)9(37,5)15(62,5)** : p< 0,05 group versus othersImpact of exacerbationFactor on prognosisIn multivariate analysis,independent risk factors predictive of ICU mortality were:the absence of cause of exacerbation,APACHE II score > 16,an EPR score>2 and the occurrence of complications during hospitalisation While exacerbation with acute bronchitis was a protective factor.Conclusion: Infectious causes remains the most common cause of acute exacerbation of COPD.The absence of exacerbation cause is an independent risk factor for mortality while acute bronchitis is a protective factor.