@article {BaxPA2437, author = {Simon Bax and Kostas Dimopoulos and Greg Kier and Maria Kokosi and Michael Wilde and Athol Wells and Laura Price and John Wort}, title = {Longitudinal change in non-invasive markers in interstitial lung disease associated pulmonary hypertension and correlation with invasive pulmonary haemodynamics}, volume = {48}, number = {suppl 60}, elocation-id = {PA2437}, year = {2016}, doi = {10.1183/13993003.congress-2016.PA2437}, publisher = {European Respiratory Society}, abstract = {Introduction: Cross sectional studies have highlighted the role of non-invasive markers in predicting interstitial lung disease (ILD) associated pulmonary hypertension (ILD-PH). Few studies have evaluated the role of longitudinal change in non-invasive variables, with repeat measurement of invasive pulmonary haemodynamics.Objectives: We hypothesized that non-invasive markers (KCO, echo parameters and main pulmonary artery size on CT) would correlate with invasive haemodynamics in ILD-PH.Methods: We performed a retrospective review of ILD and PH databases from the Royal Brompton Hospital. Identifying patients with ILD-PH who had baseline and follow up right heart catheters (RHC) (n=26). Diagnoses included Scleroderma ILD, MCTD-ILD, SLE-ILD, Sarcoid, IPF, FNSIP and chronic hypersensitivity pneumonitis. Data were compared using Wilcoxon signed rank test.Results: Of the 26 patients 6 developed PH over the study period, 11 patients mean pulmonary arterial pressure (mPAP) remained stable or increased and 9 patients had a fall in mPAP on repeat RHC. The median age in the group was 66 (28-77). Median interval between RHC 31.7 months (4-108).Patients who developed PH over the period had a median fall in KCO of -6.6\% predicted (-1.3 to -32.5, p=0.03).CT main pulmonary artery measurements increased in all groups (p=0.0003).mPAP correlated with both KCO and RVSP (measurable in 87\% of the study group at echo); (Spearman{\textquoteright}s correlation coefficient) r= -0.36, p=0.01, and r=0.53, p=0.0007 respectively.Conclusion: In this preliminary cohort, non-invasive measurements reflect changes in invasive pulmonary haemodynamics in ILD-PH.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/48/suppl_60/PA2437}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }