@article {Herrera MarreroPA2538, author = {Margarita Herrera Marrero and Berta S{\'a}ez Gim{\'e}nez and Cristina Berastegui Garc{\'\i}a and Helena Sintes Permanyer and Manuel L{\'o}pez-Meseguer and Victor Monforte Torres and Carlos Bravo Masgoret and Antonio Roman Broto}, title = {Hypogammaglobulinemia in lung transplant candidates}, volume = {48}, number = {suppl 60}, elocation-id = {PA2538}, year = {2016}, doi = {10.1183/13993003.congress-2016.PA2538}, publisher = {European Respiratory Society}, abstract = {Introduction: Infections are the main cause of morbi-mortality in lung transplant recipients (LT). The hypogammaglobulinemia (HGG) after lung transplantation has been related to an increased frequency and severity of these infections.Objective: to assess the incidence and severity of HGG in LT candidates.Material and methods: Prospectively, from January 2014 until September 2015 a determination of serum globulin (SGG) was performed (IgG, IgM, IgA) on all LT candidates and their medical records were reviewed. We considered normal IgG levels \> 700 mg/dl; mild HGG IgG 600-700mg/dl; moderate HGG IgG 400-600mg/dl and severe HGG IgG\> 400 ml/ dl.Results: There were 99 LT candidates. 63 were male (63.6\%) with a mean age of 54.1 years (range 27-66). The predominant lung diseases were chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) with 45.4\% both. 18 patients (18.1\%) had HGG (IgG): 2/18 patients (11.1\%) had mild HGG; 12/18 (66.6\%) moderate HGG and 4/18 (22.2\%) severe HGG. 4 of these patients had a combined form of HGG (IgG and IgM).Thirteen patients with HGG were COPD (13/18, 72.2\%): mild HGG 1/13, moderate HGG 8/13 and severe HGG 4/13. Four patients with ILD had HGG, one mild and three moderate.During the study 5/18 patients (27.7\%) with HGG were transplanted. Two of them received replacement therapy while were in active list; only one of them had improved GGS levels without reaching normal levelConclusions: 18/99 (18.1\%) LT candidates had HGG which was moderate-severe in the most cases 16/18 (88\%). The COPD patients had the highest prevalence of HGG 13/18 (72.2\%) (p = 0.012), being in 12/13 patients moderate-severe type.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/48/suppl_60/PA2538}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }