TY - JOUR T1 - Influence of neoadjuvant therapy to complication rate after surgery for primary lung cancer JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA2509 VL - 48 IS - suppl 60 SP - PA2509 AU - Milan Savic AU - Dragan R. Subotic AU - Nikola Atanasijadis AU - Dejan Moskovljevic AU - Ivan Soldatovic AU - Zeljko Garabinovic Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA2509.abstract N2 - Objectives: surgery after a neoadjuvant treatment is a well established approach worldwide. However, some surgical and oncological aspects still remain challenging, especially after pneumonectomy.Methods: The group 1 (main group) consisted of 22 patients with lobectomy and 26 patients with pneumonectomy after neoadjuvant chemotherapy; the group 2 (control group) included patients with straightforward surgery - 20 patients with lobectomy and 58 patients with pneumonectomy. The groups were compared in relation to the rate of postoperative complication. The group size was determined by the possibility to obtain survival data.Results: in patients with a lobectomy in the group 1, the overall complication rate was higher compared to the group 2 (11 vs 3, p<0.05). However, although prolonged air leak existed in more pts with a lobectomy in the group 1 (5 vs.3), this difference was not significant. The obtained statistical difference was caused by more cardiovascular and other complications in the group 1. In patients with a pneumonectomy in the group 1, the overall complication rate was significantly lower compared to the group with surgery alone – 4 vs. 16, p<0.05. The bronchopleural fistula occurred more frequently in the group 2 (4 vs. 1). The only bronchopleural fistula in the group 1 occured after the right-sided operations, in the group 2 there were 2 left and 2 right-sided fistulas.Conclusion: the higher complication rate in patients with a pneumonectomy and without neoadjuvant treatment is probably a consequence of the more strict selection criteria for surgical candidates after neoadjuvant treatment with obligatory bronchial stump protection in right-sided operations. ER -