RT Journal Article
SR Electronic
T1 Metabolic regulation during the co-existence of COPD and DM type2
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA639
DO 10.1183/13993003.congress-2016.PA639
VO 48
IS suppl 60
A1 Elene Sherozia
A1 Liza Peirkishvili
A1 Lali Nikoleishvili
A1 Tamar Kakhniashvili
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA639.abstract
AB Background: COPD (chronic obstructive pulmonary disease) prevalence among patients with diabetes mellitus (DM)/metabolic syndrome (MetS) is high.Aim: Definition COPD prevalence among patients with DM/MetS and evaluation of correlation between hyperglycemia and FEV1 (Forced expiratory volume in 1 sec).Material and methods: 2800 patients were screened: smokers/ex-smokers with risk of DM, DM type2, MetS. Smokers/ex-smokers with DM/MetS-22%, smokers/ex-smokers with COPD without DM/MetS-12%, smokers/ex-smokers without COPD and DM-66%. Fasting blood glucose, Glycated hemoglobin (HbA1c), Homeostasis Model Assessment (HOMA), spirometry was done.Results: COPD was initially detected in 18% of screened patients with DM/Mets. In this patients hyperglycemia were significantly associated with FEV1 rather than only in COPD (Glucose<6 mmol/l,FEV1-75%;Glucose 6-6.9mmol/l,FEV1-71%;Glucose 7-8.9 mmol/l,FEV1-68%;Glucose>9 mmol/l,FEV1-55%,P<0.005).Conclusion: COPD spreading is high in patients with glucose metabolism disturbance. It negatively affects FEV1. Complications frequency (25% vs 11%) is significantly higher (P<0.005) in COPD and DM/MetS coexistence, rather than only in COPD. Spirometry screening is necessary in patients with glucose metabolism disturbance for early detection of COPD.References: Aibek E Mirrakhimov Cardiovascular Diabetology 2012; 11:132Kasirye Y, et al. WMJ.2013; 112(6):244-9.