RT Journal Article
SR Electronic
T1 Chronic obstructive pulmonary disease admitted to an intensive care unit because of acute respiratory failure: How do severity of acidosis effect short and long term mortality?
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3060
DO 10.1183/13993003.congress-2016.PA3060
VO 48
IS suppl 60
A1 Kargin, Feyza
A1 Irmak, Ilim
A1 Çiyiltepe, Fulya
A1 Güngör, Sinem
A1 Acartürk, Eylem
A1 Berk Takir, Huriye
A1 Atagün Güney, Pinar
A1 Yaziicioglu Moçin, Özlem
A1 Adigüzel, Nalan
A1 Karakurt, Zuhal
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA3060.abstract
AB Aim: Effect of the severity of respiratory acidosis on short and long term survival in chronic obstructive pulmonary disease (COPD) patients is investigated in this study.Methods: Retrospective, observational cohort study in a intensive care unit (ICU) of a chest diseases hospital from January-December 2014. Acute respiratory failure(ARF) and COPD patients were included to study. Patients were divided into two groups according to ICU admission arterial blood gas values; ph≤7.20 (group1) and pH:7.21-7.34(group 2).Patients characteristics, ICU parameters, ICU mortality, short (28 days ) and long term (12 months) mortality were recorded.Results: 312 COPD patients were enrolled. Study groups were group 1 (n=69 ) and group 2 (n=243). Groups demographics were similar. Length of ICU stay and ICU mortality were similar in two groups.28 day mortality was %13.1 and %10.6 (p=0.35),1 year mortality 29.5% ve 36 % (p=0.35 ) in group 1 and 2 respectively. In cox regression analysis, hazard ratio of 1 year mortality was associated with presence of septic shock (HR:2.1,CI:1-4.5, p=0.039), presence of domiciliary noninvasive mechanical ventilation(DNIMV) before ICU(HR:2.5, CI:1-5.9, p=0.03), severe acidosis (HR:0.42,CI:0.5-3.03, P=0.51) and DNIMV prescription after ICU discharge(HR:0.4,CI:0.17-0.9, p=0.035).Conclusions: Severity of acidosis (pH< 7.20) does not affect short and long term mortality. Septic shock during ICU and pre ICU presence of DNIMV found to be a risk factor for 1 year mortality therefore should be followed closely. Also prescription of DNIMVafter ICU discharge decreases long term mortality significantly.