RT Journal Article SR Electronic T1 Physical activity program improves exercise tolerance and aerobic capacity in bronchopulmonary dysplasia children JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA535 DO 10.1183/13993003.congress-2016.PA535 VO 48 IS suppl 60 A1 Natalia Morales A1 Andrea Papaleo A1 Vicente Morales A1 Gregory Reychler YR 2016 UL http://erj.ersjournals.com/content/48/suppl_60/PA535.abstract AB Introduction: Bronchopulmonary Dysplasia (BPD) children have an immature organism. They present reduced exercise tolerance and physical capacity. The objective of this study was to verify the effects of an exercise program on exercise tolerance, aerobic capacity, flexibility and lung function in BPD children.Methods: This was a randomized controlled study. BPD children (4 to 6 years) (n = 26) were recruited and randomized in control (CG) and intervention (IG) groups. IG performed a 4-week exercise program based on endurance and resistance training (two sessions a week). Outcomes were Six Minute Walking test (6MWT), 10 meters Shuttle Walk test (10MSWT), Sit and Reach test (SRT) and lung function.Results: The characteristics of the two groups were similar at inclusion. No difference was observed between initial and final assessment in control group. 6MWT showed a clinical and significant improvement after the program in IG (316.3 ± 31.4m vs 376.2 ± 39.5m; p = 0.002). 10MSWT (248.0 ± 109.1m vs 465.3 ± 202.0m; p = 0.013), Sit and Reach test (14.5 ± 7.7cm vs 22.8 ± 6.9cm; p = 0.003) and FEV1 (1.02 ± 0.16 % pred vs 1.04 ± 0.17 % pred; p= 0.004) also significantly improved.Conclusion: for the first time, a 4-week exercise program showed an improvement in exercise tolerance, aerobic capacity, flexibility and FEV1 in BPD children.