RT Journal Article
SR Electronic
T1 Mortality and survival predictor in chronic hypersensitivity pneumonitis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA833
DO 10.1183/13993003.congress-2016.PA833
VO 48
IS suppl 60
A1 Ojanguren Arranz, Inigo
A1 Morell, Ferran
A1 Villar, Ana
A1 Romero, Christian
A1 Ramón, María Antonia
A1 Cruz, María Jesus
A1 Muñoz, Xavier
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA833.abstract
AB OBJECTIVE: The aim of this study was to analyze the clinical features, pulmonary function, radiological and histological features of a cohort of patients with chronic hypersensitivity pneumonitis (HP) as potential predictors of survival.METHODS: Cross sectional study that included all patients that had been diagnosed of HP according to the Shuyler and Cormier criteria, between 2004 and 2013 in a University Hospital). All patients included had at least one year of follow up since diagnosis.RESULTS: 179 patients were studied, mean age 60.1 (13.3); 103 were female. The median follow-up was (p25-p75) of 5.9 (3.9-8.6) years. Nineteen patients were excluded due to monitoring loss. Of the 160 patients followed, 87 patients remained alive and 73 had died or had received a lung transplant at the time of the study. The median survival to the date of death or transplantation was 7.0 (4.4-14.5) years. The final study using a proportional hazards model of Cox, which included all potentially influential variables identified in the univariate analysis, showed that the factors independently associated with a reduced survival were age, sex, the percentage of lymphocytes in pulmonary lavage, total lung capacity (TLC) and the CO transfer test (DLCO).CONCLUSION: The median survival of the patients with chronic HP was 7.0 (4.4-14.5) años. The percentage of lymphocites in the pulmonary lavage, the TLC and DLCO were independently associated with survival.