PT  - JOURNAL ARTICLE
AU  - Ojanguren Arranz, Inigo
AU  - Morell, Ferran
AU  - Villar, Ana
AU  - Romero, Christian
AU  - Ramón, María Antonia
AU  - Cruz, María Jesus
AU  - Muñoz, Xavier
TI  - Mortality and survival predictor in chronic hypersensitivity pneumonitis
AID  - 10.1183/13993003.congress-2016.PA833
DP  - 2016 Sep 01
TA  - European Respiratory Journal
PG  - PA833
VI  - 48
IP  - suppl 60
4099  - http://erj.ersjournals.com/content/48/suppl_60/PA833.short
4100  - http://erj.ersjournals.com/content/48/suppl_60/PA833.full
SO  - Eur Respir J2016 Sep 01; 48
AB  - OBJECTIVE: The aim of this study was to analyze the clinical features, pulmonary function, radiological and histological features of a cohort of patients with chronic hypersensitivity pneumonitis (HP) as potential predictors of survival.METHODS: Cross sectional study that included all patients that had been diagnosed of HP according to the Shuyler and Cormier criteria, between 2004 and 2013 in a University Hospital). All patients included had at least one year of follow up since diagnosis.RESULTS: 179 patients were studied, mean age 60.1 (13.3); 103 were female. The median follow-up was (p25-p75) of 5.9 (3.9-8.6) years. Nineteen patients were excluded due to monitoring loss. Of the 160 patients followed, 87 patients remained alive and 73 had died or had received a lung transplant at the time of the study. The median survival to the date of death or transplantation was 7.0 (4.4-14.5) years. The final study using a proportional hazards model of Cox, which included all potentially influential variables identified in the univariate analysis, showed that the factors independently associated with a reduced survival were age, sex, the percentage of lymphocytes in pulmonary lavage, total lung capacity (TLC) and the CO transfer test (DLCO).CONCLUSION: The median survival of the patients with chronic HP was 7.0 (4.4-14.5) años. The percentage of lymphocites in the pulmonary lavage, the TLC and DLCO were independently associated with survival.