RT Journal Article
SR Electronic
T1 Oxygen-enhanced MR (OE-MR): Correlation to CT Brody score in cystic fibrosis patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP OA1492
DO 10.1183/13993003.congress-2016.OA1492
VO 48
IS suppl 60
A1 Katharina Martini
A1 Christian Benden
A1 Geoff Parker
A1 Stephan Baumüller
A1 Jose Ulloa
A1 Alex Morgan
A1 Thomas Frauenfelder
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/OA1492.abstract
AB Purpose: To investigate the capability of 3D-dynamic oxygen-enhanced MR (OE-MR) and Computed tomography (CT) in patients with Cystic Fibrosis (CF) and pulmonary function tests (PFT).Materials/Methods: 13 patients (median age: 28, female n=7) with a range of CF lung disease underwent OE-MR (1.5 T MR scanner). Coronal T1 parameter maps were obtained during free breathing. 3D coronal volumes of both lungs were acquired while patients alternately breathed room air and 100% oxygen. Images were fitted pixel by pixel. T1-parameter maps were generated and the following OE-MR parameters were measured: maximum O2-uptake(dPO2), wash-in and wash-out time. CT and PFT were available. Brody score was assessed by two radiologists. Total CT Brody score (CF-CT) was compared with PFT (%FEV1) and the OE-MR parameters using Pearson correlation.Results: Intraclass correlation for CF-CT(range:2-53,median 32) was high (0.86). dPO2, wash-in and wash-out time showed a significant correlation with CF-CT (dPo2:r=-0.691;p=0.009; wash-in/wash out:r=0.712;p=0.006). There was a significant correlation between dPO2, wash-in time and %FEV1 (O2-uptake: r=0.85;p<0.001; wash-in: r=-0.86;p<0.001).Conclusion: Functional lung imaging using OE-MR has the capability to assess the severity of CF lung disease showing a significant correlation with %FEV1 and CT Brody score. For long-term CF care, avoidance of cumulative radiation burden is desirable and feasible using OE-MR.