PT - JOURNAL ARTICLE AU - Barikbin, Payman AU - Sallmon, Hannes AU - Wilitzki, Silke AU - Photiadis, Joachim AU - Bührer, Christoph AU - Koehne, Petra AU - Schmalisch, Gerd TI - Lung function measurements in very low birth weight infants after patent ductus arteriosus ligation AID - 10.1183/13993003.congress-2016.PA1303 DP - 2016 Sep 01 TA - European Respiratory Journal PG - PA1303 VI - 48 IP - suppl 60 4099 - https://publications.ersnet.org//content/48/suppl_60/PA1303.short 4100 - https://publications.ersnet.org//content/48/suppl_60/PA1303.full SO - Eur Respir J2016 Sep 01; 48 AB - Objective: The indications and strategies for treatment of patent ductus arteriosus (PDA) are controversial, and the safety and long-term benefits of surgical PDA closure remain uncertain. The aim of this study was to compare the lung function of very low birth weight (VLBW) infants after PDA treatment with a cyclooxygenase inhibitor or surgical ligation.Study design: A total of 114 VLBW infants (birth weight < 1500 g), including 94 infants (82%) with a birth weight < 1000 g, who received treatment for hemodynamically significant PDA (hsPDA) were examined at a median postmenstrual age of 48 weeks. All infants were initially given pharmacological treatment, and 40 infants (35%) required PDA ligation. Lung function testing (LFT) included tidal breathing measurements, measurement of respiratory mechanics assessed by the occlusion test, whole-body plethysmography, SF6 multiple breath washout, forced expiratory flow (V'maxFRC) by the rapid thoracoabdominal compression technique, exhaled NO (FeNO), and arterialized capillary blood gas analysis.Results: On the day of the LFT, the 2 groups had similar postconceptional age and body weight. However, the PDA ligation group was more immature at birth (p < 0.001) and had reduced respiratory compliance (p < 0.001), lower V'maxFRC (p = 0.006), increased airway resistance (Raw) (p < 0.001), and impaired blood gases (p < 0.001). Multivariate analysis showed that PDA surgery was an independent risk factor for increased Raw and reduced respiratory compliance.Conclusions: PDA ligation is associated with impaired lung function in infants with a postmenstrual age of 48 weeks.