TY - JOUR T1 - Long-term results obtained by cardiovascular magnetic resonance imaging and somatostatin receptor PET in cardiac sarcoidosis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA3819 VL - 48 IS - suppl 60 SP - PA3819 AU - Carmen Pizarro AU - Folke Kluenker AU - Darius Dabir AU - Florian Gärtner AU - Christian Grohé AU - Georg Nickenig AU - Dirk Skowasch Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA3819.abstract N2 - Cardiac affection constitutes a major limiting condition in systemic sarcoidosis.We performed cardiovascular magnetic resonance (CMR) imaging and somatostatin receptor scintigraphy to define the course in cardiac sarcoidosis (CS).In a pilot study, we identified cardiac involvement – diagnosed by CMR imaging – to be present in 29 of 188 patients (15.4%) with histologically proven, extracardiac sarcoidosis. Out of these initial 29 CS-positive patients, 27 patients (49.9 ± 11.8 years, 59.3% male) were presently re-examined and underwent a second CMR-study. 68Ga-DOTATOC PET/CT was performed when clinically indicated (17 patients).Within a median follow-up period of 2.6 years, none of the initial 29 patients deceased or experienced aborted sudden cardiac death. Among the 27 re-examined cardiac sarcoidosis patients, pathological CMR-findings persisted in 14 of 27 patients (51.9%): 7 patients (25.9% of total study population) exhibited myocardial scar; 1 patient (3.7%) showed increased relative gadolinium enhancement as well as myocardial oedema, as markers of acute inflammatory injury. Both acute and chronic phase cardiac involvement was present in 6 patients (22.2%). Standard CS evaluation parameters as well as laboratory testing failed to recognize CS-persistence.68Ga-DOTATOC PET/CT identified 2 patients with regions of raised tracer uptake that concorded with acute inflammatory changes, as assessed by CMR.Cardiac sarcoid affection persisted in barely half the patients and was not afflicted with cardiac death. Additional 68Ga-DOTATOC PET/CT-imaging allowed for visualization of acute myocardial inflammation and might represent a sensitive CS imaging tool. ER -