PT  - JOURNAL ARTICLE
AU  - Leah Githinji
AU  - Diane Gray
AU  - Sipho Hlengwa
AU  - Heather Zar
TI  - Lung function in HIV- infected adolescents on antiretroviral therapy in Cape Town, South Africa
AID  - 10.1183/13993003.congress-2016.PA674
DP  - 2016 Sep 01
TA  - European Respiratory Journal
PG  - PA674
VI  - 48
IP  - suppl 60
4099  - http://erj.ersjournals.com/content/48/suppl_60/PA674.short
4100  - http://erj.ersjournals.com/content/48/suppl_60/PA674.full
SO  - Eur Respir J2016 Sep 01; 48
AB  - Background: Over 90% of HIV infected adolescents live in Sub-Saharan Africa. Although lung disease is very common, there is limited information on the spectrum of lung function impairment in HIV-infected adolescents.Objective: To investigate lung function in South African HIV infected adolescents on antiretroviral therapy (ART) enrolled in a prospective cohort, the Cape Town Adolescent Anti-retroviral cohort.Methods: Adolescents aged 9 to 14 years, stable on ART for at least 6 months, underwent baseline lung function testing. Lung function measures included spirometry, Nitrogen multiple breath wash out, forced oscillation technique and single breath carbon monoxide diffusion testing.A sample of HIV negative, age, sex and ethnically matched controls were also tested.Results: 520 HIV-infected adolescents and 110 HIV negative controls were tested. The mean (SD) age in years was 12 (1.6) ; 52% were male. Median duration of ART therapy was 7.6 years. Median CD4 was 510.5 cells/mm3. Median HIV viral load was 226 copies/ml.Lung function measureHIV infectedHIV uninfectedP value*FEV1 (l)1.6 (1.3-1.9)1.8 (1.5-2.2)0.001FEV1/FVC (%)89 (85-95)93 (90-98)<0.001Transfer factor for carbon monoxide (mlCO/min/mmHg)16.2 (14.1-18.7)17.6 (14.8-20.9)0.052Functional residual capacity (l)1.0 (0.8-1.2)1.2 (0.9-1.5)0.003Lung clearnce index7.4 (6.8-8.1)6.9 (6.3-7.6)0.008Resistance at 8Hz (cmH20.L/s)5.0 (4.2-5.7)4.4 (3.5-5.4)0.001*adjusted for HIV status, age, height, genderConclusion: Lung function abnormalities are common in HIV-infected adolescents. African HIV infected adolescents on ART have lower lung function than HIV uninfected adolescents.