RT Journal Article
SR Electronic
T1 Early surgical resection for stage I high-grade neuroendocrine caricinoma of lung
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4847
DO 10.1183/13993003.congress-2016.PA4847
VO 48
IS suppl 60
A1 Mochizuki, Eisuke
A1 Ooishi, Kyohei
A1 Miyashita, Koichi
A1 Ichijyo, Koshiro
A1 Furukawa, Syunya
A1 Nagaoka, Miyuki
A1 Matsuura, Syun
A1 Mikura, Shinichiro
A1 Tsukui, Masaru
A1 Koshimizu, Naoki
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA4847.abstract
AB RATIONALE: Since high-grade neuroendocrine tumors are rapidly progressive, most cases are inoperable when diagnosed. There are few reports about the prognosis of patients or the course of the disease after surgery.OBJECTIVES: To clarify the clinical course of the disease after surgery and factors influencing the prognosis.METHODS: We retrospectively assessed 27 patients receiving surgery for small cell carcinoma (22 cases) and large neuroendocrine carcinoma (5 cases) from January 2005 through January 2015 at our hospital.RESULTS: Patients were all male, with an average age of 70.9 years. Of the 27 patients, 22 had received postoperative adjuvant chemotherapy. Median progression-free survival (PFS) and overall survival (OS) were 1.1 and 5.5 years, respectively. Ten patients were recurrence-free. Ten patients who underwent surgery within 60 days after the diagnosis demonstrated a better prognosis regarding OS (p<0.01) than those operated on after 60 days. The size of the tumor, titer of tumor markers, chemotherapy, smoking history, and age did not influence PFS or OS.CONCLUSIONS: Early surgical resection for high-grade neuroendocrine carcinoma stage I may lead to a better prgonosis.