PT  - JOURNAL ARTICLE
AU  - Mochizuki, Eisuke
AU  - Ooishi, Kyohei
AU  - Miyashita, Koichi
AU  - Ichijyo, Koshiro
AU  - Furukawa, Syunya
AU  - Nagaoka, Miyuki
AU  - Matsuura, Syun
AU  - Mikura, Shinichiro
AU  - Tsukui, Masaru
AU  - Koshimizu, Naoki
TI  - Early surgical resection for stage I high-grade neuroendocrine caricinoma of lung
AID  - 10.1183/13993003.congress-2016.PA4847
DP  - 2016 Sep 01
TA  - European Respiratory Journal
PG  - PA4847
VI  - 48
IP  - suppl 60
4099  - http://erj.ersjournals.com/content/48/suppl_60/PA4847.short
4100  - http://erj.ersjournals.com/content/48/suppl_60/PA4847.full
SO  - Eur Respir J2016 Sep 01; 48
AB  - RATIONALE: Since high-grade neuroendocrine tumors are rapidly progressive, most cases are inoperable when diagnosed. There are few reports about the prognosis of patients or the course of the disease after surgery.OBJECTIVES: To clarify the clinical course of the disease after surgery and factors influencing the prognosis.METHODS: We retrospectively assessed 27 patients receiving surgery for small cell carcinoma (22 cases) and large neuroendocrine carcinoma (5 cases) from January 2005 through January 2015 at our hospital.RESULTS: Patients were all male, with an average age of 70.9 years. Of the 27 patients, 22 had received postoperative adjuvant chemotherapy. Median progression-free survival (PFS) and overall survival (OS) were 1.1 and 5.5 years, respectively. Ten patients were recurrence-free. Ten patients who underwent surgery within 60 days after the diagnosis demonstrated a better prognosis regarding OS (p<0.01) than those operated on after 60 days. The size of the tumor, titer of tumor markers, chemotherapy, smoking history, and age did not influence PFS or OS.CONCLUSIONS: Early surgical resection for high-grade neuroendocrine carcinoma stage I may lead to a better prgonosis.