TY - JOUR T1 - Intrapleural photodynamic therapy for malignant pleural mesothelioma: A new dosimetry approach JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA5079 VL - 48 IS - suppl 60 SP - PA5079 AU - Camille Munck AU - Arnaud Scherpereel AU - Xavier Dhalluin AU - Henri Porte AU - Serge Mordon AU - Nacim Betrouni Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA5079.abstract N2 - Background When surgery is part of a multimodal treatment for malignant pleural mesothelioma (MPM), it is essential to combine it with a local adjuvant treatment to kill remaining microscopic tumor cells. In this goal, intrapleural photodynamic therapy (iPDT) has recently emerged as a promising technique with major impact on survival and minimum toxicity. Since the success of iPDT depends on complete and uniform illumination of the pleural cavity, we aimed at developing a new light dosimetry method based on imaging.Methods Light dosimetry was performed around the light wand's tip, made with an endotracheal tube, a cylindrical light diffuser and an electromagnetic sensor. This illumination profile was to be integrated into an electromagnetic tracking system (EMTS), to monitor the motion of the light source inside the thorax. A human-sized intraoperative thorax phantom was created as a template.Results The profile of the light wand showed an ellipse-shaped illumination, with percentage of remaining light according to the distance from the diffuser. EMTS was able to track the wand's movements inside the cavity with a precision of less than 1mm. The spatial coordinates of the thorax phantom were matched to its CT scan. The light dose delivered on its surfaces was calculated according to the illumination profile and displayed in real time on the CT scan 3D images.Conclusion This study shows the feasibility of this approach, suggesting a complete peroperative dosimetry in real time for iPDT in the future. Clinical validation is ongoing during clinical trials on iPDT for MPM starting in Lille University Hospital. Preliminary results of the clinical trial will be showned at the ERS meeting. ER -