TY - JOUR T1 - Long term changes of C-rective protein (CRP) in obstructive sleep apnoea (OSA) with or without treatment JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA2300 VL - 48 IS - suppl 60 SP - PA2300 AU - Ana Lucía Figueredo Cacacho AU - Teresa Martin Carpi AU - Dinora Polanco Alonso AU - Ana Lilian Simon Robles AU - Victoria Gil Gomez AU - Pablo Cubero Marin AU - Marta Forner AU - Santiago Carrizo Sierra AU - Salvador Bello AU - José María Marin Trigo Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA2300.abstract N2 - INTRODUCTION: Obesity is associated with systemic inflammation, but its relationship with OSA is controversial. CRP is a predictor of cardiovascular events, that are also is increased in OSA. To determine changes in CRP level in OSA and the effect of treatment.METHODS: We evasluated subjects from the EPIOSA study (clinicalTrials.gov: NCT02131610) aged between 18 and 60 years old with suspected OSA. Any smoking history or comorbid condition and a body mass index (BMI)≥ 35 Kg/m2 were exclusion criteria. CRP levels were analyzed at the time of diagnosis and after one-year of follow-up.RESULTS: A total of 27 healthy adults (AHI<5) and 114 patients with OSA were evaluated. No differences in CRP between healthy and mild OSA (AHI <15/hour) were found. Median (interquartile range) of CRP levels were higher in OSA with AHI >15 compare to healthy controls: 0.37 (0.42) vs 0.20 (0.20). At 1-year of follow-up participants with OSA treated with CPAP and a median use of CPAP > 4 hours/night (group “CPAP”, n=46) showed no change in CRP levels; those not treated with CPAP or CPAP use of < 4 hours per day, showed a slightly increase in CRP: 0.37 (40) to 0.45 (0.61). CONCLUSIONS: Patients with severe OSA without comorbidities, and BMI < 35 kg/m2, had higher levels of CRP compared to healthy or mild OSA but do not showed a reduction in CRP levels after effective treatment with CPAP during one-year follow up. ER -