RT Journal Article SR Electronic T1 Psychological, quality of life, and work-limitation outcomes among occupational asthma and work-exacerbated asthma subgroups JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP PA1156 DO 10.1183/13993003.congress-2016.PA1156 VO 48 IS suppl 60 A1 Joshua Lipszyc A1 Frances Silverman A1 Dorothy Linn Holness A1 Gary Liss A1 Kim Lavoie A1 Susan Tarlo YR 2016 UL http://erj.ersjournals.com/content/48/suppl_60/PA1156.abstract AB Introduction: Work-related asthma (WRA) comprises occupational asthma (OA), where asthma is caused by exposures at work, and work-exacerbated asthma (WEA), where a pre-existing asthma is worsened by exposures at work. WRA has implications in mental health, quality of life (QoL), and work limitations, but there has been a dearth of research exploring these domains among OA and WEA subgroups.Objective: We explored psychological, QoL, and work-limitation outcomes among OA and WEA subgroups.Methods: Subjects were recruited from 2 Toronto hospitals. Demographic characteristics were collected by chart review. Beck anxiety and depression (II) inventories, Marks' Asthma Quality of Life Questionnaire, and Work Limitations Questionnaire were used to measure domains. SPSS was used to analyze the data.Results: Seventy-seven subjects participated at a mean of 9.31±5.4(SD) years after diagnosis, including 50 (64.9%) with OA and 27 (35.1%) with WEA. Sixty-two percent were male. Mean age of OA and WEA subjects were 58.7±9.5 and 53.2±11.1, respectively. WEA subjects had a trend toward higher levels of anxiety (OAM(MEAN)=9.2±8.0,WEAM=12.8±8.3,P=0.07), and depression (OAM=9.6±10.3,WEAM=13.4±13.5,P=0.2). QoL (OAM=1.1±0.84,WEAM=1.0±0.89, P=0.81) and work-limitation (for those working) (N=50,OAM=25.1±27.3,WEAM=20.6±24.4,P=0.56) outcomes were comparable among OA and WEA subjects.Discussion: Our study suggests that those with WEA have higher levels of anxiety and depression compared to OA subjects, with depression scores of WEA subjects falling within the range of clinical significance (mild depression). QoL and work-limitation outcomes were similar among subgroups.