@article {Um-Bergstr{\"o}mPA366, author = {Petra Um-Bergstr{\"o}m and Jenny Hallberg and Per Thunqvist and Eva Berggren-Brostrom and Martin Anderson and Gunilla Adenfelt and Gunnar Lilja and Giovanni Ferrara and Magnus Skold and Erik Mel{\'e}n}, title = {Long term pulmonary outcome after mild to severe bronchopulmonary dysplasia}, volume = {48}, number = {suppl 60}, elocation-id = {PA366}, year = {2016}, doi = {10.1183/13993003.congress-2016.PA366}, publisher = {European Respiratory Society}, abstract = {Introduction: Bronchopulmonary dysplasia (BPD) is a risk factor for respiratory disease in children born preterm.Aims: To extensively evaluate lung function in prematurely born adolescents with and without BPD in infancy and to assess change over time from school age.Methods: Fifty-one individuals born between gestational weeks 24 to 31 in Stockholm, Sweden, were examined in adolescence (12-15 years of age) using spirometry, impulse oscillometry, plethysmography, multiple breath wash-out and ergospirometry. Comparison with spirometry and impulse oscillometry data from school age (6-8 years of age) was also made. Twenty-three infants were diagnosed with respiratory distress syndrome but not BPD, while 28 were graded as mild (n=17), moderate (n=7) and severe (n=4) BPD.Results: Adolescents with a history of BPD, had lower forced expiratory volume in 1 sec (-0.80 vs. -0.02 z-scores, p \<0.05), higher frequency dependence of resistance, R5-20, (0.11 vs. 0.063 kPa/L/s, p \<0.05) and higher lung clearance index (9.6 vs. 7.1, p\<0.05) compared to those without BPD.Between school age and adolescence, FEV1/FVC z-scores decreased for all groups, especially in the group with severe BPD (-2.95 z-scores, 95\%CI -3.42;-1.42 at 12-15 years). Conclusions: Lung function reflecting the central and the peripheral airways were affected in adolescents previously diagnosed with BPD. The further reduction of the FEV1/FVC-ratio over time in the group with severe BPD might implicate a route towards chronic airway obstruction. Our results suggest the need for follow up of lung function in adulthood.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/48/suppl_60/PA366}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }