PT  - JOURNAL ARTICLE
AU  - Saki Oyama
AU  - Yoshio Otani
AU  - Wakaba Furuie
AU  - Miho Akaza
AU  - Tetsuo Sasano
AU  - Kimitake Tsuchiya
AU  - Meiyo Tamaoka
AU  - Naohiko Inase
AU  - Yuki Sumi
TI  - Cluster analysis of cough variant asthma using FeNO
AID  - 10.1183/13993003.congress-2016.PA4193
DP  - 2016 Sep 01
TA  - European Respiratory Journal
PG  - PA4193
VI  - 48
IP  - suppl 60
4099  - http://erj.ersjournals.com/content/48/suppl_60/PA4193.short
4100  - http://erj.ersjournals.com/content/48/suppl_60/PA4193.full
SO  - Eur Respir J2016 Sep 01; 48
AB  - Background: Asthma is a heterogeneous inflammatory disorder with several different phenotypes, and cough variant asthma (CVA) is a form of asthma which presents mainly cough. Cluster analysis of CVA using FeNO has not been reported.Objective: We classified CVA phenotypes using cluster analysis including FeNO value.Methods: Patients with CVA were retrospectively recruited. Data were taken from medical records, and cluster analysis was performed on 223 subjects.Results: From the cluster dendrogram [Fig1], five clusters were identified [Fig2]. Patients with CVA were classified as Cluster 1: highly eosinophilic bronchitis group [high value of FeNO alone, n=25], Cluster 2: atopic group [high IgE alone, n=25], Cluster 3: non-atopic and non-eosinophilic group [n=105], Cluster 4: distal airway narrowing group [low Forced Expiratory Flow at 75% of FVC (V25), n=23], and Cluster 5: severe atopic group [extreme high value of IgE and/or extreme high value of FeNO, n=45].Discussion: At least 20 percent of patients with CVA could be diagnosed using FeNO. More than 10 percent of patients with CVA showed distal airway narrowing.