TY - JOUR T1 - The role of intratracheal dilation – Injection technique in treatment of granulomatosis with polyangiitis (GPA) patients with subglottic stenosis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA3548 VL - 48 IS - suppl 60 SP - PA3548 AU - Justyna Fijolek AU - Elzbieta Wiatr AU - Dariusz Gawryluk AU - Magdalena Maria Martusewicz-Boros AU - Tadeusz Maria Orlowski AU - Dariusz Dziedzic AU - Malgorzata Polubiec-Kownacka AU - Karina Oniszh AU - Renata Langfort AU - Kazimierz Roszkowski-Sliz Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA3548.abstract N2 - OBJECTIVE: Analysis of occurence frequency of SGS in GPA patients, time of appearance of clinical symptoms and assessement of effectivenes of treatment with particular taking into account intratracheal dilation – injection therapy (IDIT).METHODS: Review and treatment with IDIT of 34 patients with SGS associated with GPA.RESULTS: SGS developed in 34 of 250 patients with GPA (13,6%). The diagnosis of SGS occurred in the absence of other features of active GPA in 15 of 34 patients (44%): in 11 cases after and in 4 cases – during immunosuppressive therapy (IST), when disease in other organs was in clinical remission. All patients underwent IDIT and in all it brings immediate improvement. The mean time of response duration since the last procedure was 42,6 months and the mean interval between sessions was 6,5 months. None of the patients required tracheostomy after beginning IDIT in our hospital.CONCLUSIONS: SGS often occurs independently of other features of active GPA. IDIT is a safe and an effective technique in the treatment of GPA – related SGS. It should be performed in all GPA patients, who develope significant SGS, also in these with multi-organ disease concomitantly with immunosuppresive therapy. In patients with isolated SGS it allows to avoid IST and tracheostomy. ER -