RT Journal Article
SR Electronic
T1 LATE-BREAKING ABSTRACT: Antioxidant supplementation in chronic obstructive pulmonary disease (COPD): A relevant way to optimize pulmonary rehabilitation effects
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA714
DO 10.1183/13993003.congress-2016.PA714
VO 48
IS suppl 60
A1 Jonathan Maury
A1 Fares Gouzi
A1 Nelly Héraud
A1 Philippe De Rigal
A1 Nicolas Molinari
A1 Joël Pincemail
A1 Dalila Laoudj-Chenivesse
A1 François Bughin
A1 Magali Poulain
A1 Marine Blaquière
A1 Jacques Mercier
A1 Christian Préfaut
A1 Pascal Pomiès
A1 Maurice Hayot
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA714.abstract
AB In COPD patients oxidative stress (OS) is a limiting factor of exercise training effects on muscle impairment during pulmonary rehabilitation (PR). Antioxidant supplementation used during PR appeared inappropriate to cope with COPD-related antioxidant deficits. We therefore investigated whether exercise training PR, combined with non-pharmacological antioxidant supplementation (vitamins C and E, zinc, selenium), would have beneficial effects on muscle impairment and exercise capacity.58 stable COPD patients (61 years; FEV1: 59%predicted) referred for a 4-week PR program, were recruited in a double-blind randomized, placebo-controlled clinical trial. Primary outcome was change in quadriceps endurance (Qend). Secondary outcomes were: quadriceps maximal voluntary contraction (QMVC), exercise capacity (maximal oxygen uptake (Vo2sl), systemic OS markers and muscle fiber cross sectional area (CSA).Qend was significantly increased in both COPD patient groups. QMVC and VO2sl were improved (+9 and +16%, respectively) exclusively in “PR+antioxidant” group (p=0.01 and p<0.05). The “PR+antioxidant” group showed a significant increase in vitamin E and selenium compared to “PR+placebo” group (p=0.05 and p<0.001, respectively) without differences in vitamin C and lipid peroxidation. Muscle fiber CSA was significantly increased in “PR+antioxidant” group compared to “PR+placebo” group (+17% vs -6% respectively, p<0.05).In conclusion, this study showed that antioxidant supplementation combining vitamin C, E, zinc and selenium, improves the PR effects on QMVC, Vo2sl and muscle fiber CSA by enhancing antioxidant capacity of COPD patients.