TY - JOUR T1 - Volatile organic compounds in COPD: Is hexanal an inflammation biomarker? JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA4412 VL - 48 IS - suppl 60 SP - PA4412 AU - Maria Angeles Munoz AU - Javier Jareño AU - Óscar Gómez AU - Sergio Utrilla AU - Francisco Villegas AU - Carlos Gutiérrez AU - Luis Callol Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA4412.abstract N2 - Introduction: Volatile organic compounds (VOC) within exhaled breath are produced as a consequence of oxidative stress procedure in cell membranes. This determining could be of interest in COPD biomarkers research.Objective: Determine whether there are differences between VOCin exhaled breath of COPD patients and healthy controls.Method: Case-control study. 157 volunteers divided into 2 groups: healthy controls and COPD patients. Informed consent accepted.Samples were collected using Bio-VOC® devices and were transferred to universal desorption tubes. Compounds were analyzed by gas chromatography and mass spectrometry.VOC analyzed: hexanal, heptanal, nonanal, nonanoic acid and propionic acid (end-product of lipid peroxidation).Statistical analyses using SPSS version 20.Results: 57 COPD patients. Average age: 73,6 (9,5) years; Smoking index 74,4 (39,2) pack-years.Control group: 100 healthy volunteers (33 smokers, 39 never smokers and 28 former smokers). Average age: 49 (9) years; Smoking index 29 (20) pack-years.Hexanal showed statistically significant difference comparing the COPD group and all healthy controls (p=0,023).When comparing never smokers from control group to COPD group we found statistically significant differences in both hexanal (p=0,015) and nonanal (p=0,008).When comparing former smokers to COPD group we found statistically significant differences in hexanal (p=0,013). However, there weren´t any differences when comparing healthy smokers to COPD group.Conclusions: Hexanal showed differences between COPD group and healthy controls. The difference between them is greater when comparing COPD group and non-active smokers from control group. ER -