PT  - JOURNAL ARTICLE
AU  - Ioannis Tomos
AU  - Effrosyni Manali
AU  - Anna Karakatsani
AU  - Aris Spathis
AU  - Ioanna Korbila
AU  - Antonis Analitis
AU  - Petros Karakitsos
AU  - Spyros Papiris
TI  - IL-6 and IL-8 in stable and exacerbated IPF patients and their association to outcome
AID  - 10.1183/13993003.congress-2016.PA3890
DP  - 2016 Sep 01
TA  - European Respiratory Journal
PG  - PA3890
VI  - 48
IP  - suppl 60
4099  - http://erj.ersjournals.com/content/48/suppl_60/PA3890.short
4100  - http://erj.ersjournals.com/content/48/suppl_60/PA3890.full
SO  - Eur Respir J2016 Sep 01; 48
AB  - The precise pathogenetic mechanisms and the potential role of uncontrolled fibroblastic proliferation or occult infection in IPF acute exacerbations need clarification. The aim of the study was the assessment of profibrotic and proinflammatory profile in both stable and excacerbated patients and their association to outcome.Stable or exacerbated patients referred to our department from October 2013 until November 2014 were included. IL-6, IL-8 and TGF-b were measured. All patients were followed up for 12 months. Tobit and logistic regression analysis were applied.Forty-one patients were included in the study [18 exacerbated, median age (IQR) 68.5 (67.0, 78.0) and 23 with stable IPF, median age (IQR) 71.0 (69.0, 74.0)]. Exacerbated patients presented higher plasma levels of IL-6 and IL-8 compared to those with stable IPF [median (IQR) 6.2 (3.2, 26.5) vs 2.1 (1.0, 4.4) pg/ml, p=0.002; median (IQR) 16.5 (12.9, 44.8) vs 10.1 (7.9, 13.2) pg/ml, p=0.046, respectively]. Most of the differences were independent to age, smoking status, procalcitonin, CRP, corticosteroid and oxygen treatment. No significant differences were observed in the profibrotic cytokine TGF-b between the two groups. An increase of IL-6 or IL-8 by 1 pg/ml increased the odds of death by 5,6% (p=0.021) and 6,7% (p=0.013) respectively in all patients and by 3,8% (p=0.093) and 4,3% (p=0.078) in exacerbated patients.The increased plasma levels of IL-6 and IL-8 found in exacerbated patients compared to stable suggest the presence of inflammation that may also relate to occult infection. Furthermore, our results indicate that plasma levels of IL-6 and IL-8 are associated with increased risk of death in all.