RT Journal Article
SR Electronic
T1 Asthma-associated factors - Potential predictive markers for patients stratification, personalized treatments and prevention
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3366
DO 10.1183/13993003.congress-2016.PA3366
VO 48
IS suppl 60
A1 Rostyslav Bubnov
A1 Liudmyla Petrenko
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA3366.abstract
AB Introduction: Asthma is a chronic disease with poor prognosis for life quality. Appropriate patients stratification according to the broad panel of relevant markers is important.The Aim: was to determine the prevalence of health parameters and potential external triggers in asthma patients, affecting life quality.Material and methods: We included 300 consecutive patients with asthma (age 18-85 years; 203 females, 97 males) and 100 healthy volunteers (control group). All patients underwent general clinical examination, diagnostic tests: spirogram; general lab tests; immunology tests; ultrasound; and responded to QOL (36 questions).Results: We found significantly higher incidence in patients with asthma: younger age (20-40 years); female gender; the predominant months of birth in patients with were January, April and July; appendectomy and / or tonsillectomy in anamnesis strongly correlated with asthma incidence. Among collateral diseases allergy occurred in 69 % patients with asthma; obesity - in 32 %; gout – in 18 %; DM type 2 - in 28 %;intestinal disorders (reflux, IBD) – in 58%; microsplenia - in 54 %; fungal sensitization - in 15% patients respectively. Physical and intellectual exertion, alcohol consumption, sauna, long stay in cold and damp room were most affecting life quality and provoking exacerbations.Conclusion: Younger age, female gender; birth in January, April and July; appendectomy, tonsillectomy in anamnesis; allergy; obesity; physical and intellectual exertion, alcohol consumption, sauna, long stay in cold and damp room are relevant parameters, significantly associated with asthma, risk factors, affecting exacerbations.