RT Journal Article
SR Electronic
T1 MDR-TB: Early screening or future screaming
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA2746
DO 10.1183/13993003.congress-2016.PA2746
VO 48
IS suppl 60
A1 Amitabh das Shukla
A1 Abhinav Chaudhary
A1 Tariq Mahmood
A1 Alok Chandra
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA2746.abstract
AB Introduction: India is one of the high tuberculosis(TB)burden countries,accounting for nearly 25% of the global Incidence.MDR-TB has emerged as a significant global health concern.The Government of India implementing directly observed treatment,short course(DOTS-plus)facility to control the MDR-TB since October 2007.Aims: Aims of this study was to evaluate proportion of MDR-TB,in patients enrolled for retreatment in DOTS under RNTCP.Methods: The present study was an observational cross sectional study.Total 120 patients of retreatment pulmonary TB were subjected to sputum microscopy for acid-fast bacillus at time of enrollment in category II treatment,further they were subjected to CB-NAAT.Rifampicin resistant patients,were diagnosed as a cases of MDR-TB.Results: Out of 120 patients,25%(n=30)were found to be suffering from MDR-TB.Proportion of MDR-TB was higher in females(35.29%)than male(20.93%). Mean age of MDR-TB patients was 39.11±15.27 in males and 33.83±14.98 in females.We found the trend of increasing proportion of MDR-TB,as age advanced.casesCB-NAAT positiveCB-NAAT negative% of MDRTotal cases120309025.0Males86186820.93Females34122235.29proportion of MDRProportion of MDR-TB also increased along with increase in sputum bacillary load. sputum AFB statusNo. of patientCB-NAAT positive% MDR1+41921.92+34823.53+361336.1% of MDR in different bacillary loadConclusion: Proportion of MDR-TB in retreatment category of TB patients was high,particularly in female,old age and in patients high bacillary load.It is implied that all patients of pulmonary TB should be evaluated for possibility of drug resistance that can facilitate the diagnosis of MDR-TB at an early stage and will minimize transmission of the disease.