PT - JOURNAL ARTICLE AU - Fiona Cleutjens AU - Frits Franssen AU - Martijn Spruit AU - Lowie Vanfleteren AU - Candy Gijsen AU - Jeanette Dijkstra AU - Rudolf Ponds AU - Emiel Wouters AU - Daisy Janssen TI - Domain-specific cognitive impairment in patients with COPD and control subjects AID - 10.1183/13993003.congress-2016.PA3742 DP - 2016 Sep 01 TA - European Respiratory Journal PG - PA3742 VI - 48 IP - suppl 60 4099 - http://erj.ersjournals.com/content/48/suppl_60/PA3742.short 4100 - http://erj.ersjournals.com/content/48/suppl_60/PA3742.full SO - Eur Respir J2016 Sep 01; 48 AB - Background: Cognitive impairment may interfere with disease-management in patients with chronic obstructive pulmonary disease (COPD), depending on which cognitive domains are affected. The prevalence of domain-specific cognitive impairment in patients with COPD entering pulmonary rehabilitation remains unknown.Aim: To compare the prevalence of domain-specific cognitive impairment between patients with COPD and non-COPD controls.Methods: A neuropsychological assessment was administered in stable COPD patients and controls with comparable smoking status, age, and education. Six tests from the Maastricht Aging Study were used to assess general cognitive impairment. Compound Z scores were constructed for psychomotor speed, planning, working memory, verbal memory, and cognitive flexibility.Results: 90 COPD patients (mean age 63.7 (SD 8.8) yrs; 54.4% men; FEV1 54.5% (23.7) pred.) and 90 controls (mean age 62.3 (SD 7.4) yrs; 50.0% men; FEV1 116.3% (18.2) pred.) were included. General cognitive impairment was found in 56.7% and 13.3% of COPD patients and controls, respectively (p<0.001). In patients, all cognitive domains were more affected than in controls. Conclusions: General and domain-specific cognitive impairment affects patients with COPD to a higher degree than controls. Clinicians should be aware of the possible presence of cognitive impairment and disease-management programs should take into account the needs of these patients.