RT Journal Article
SR Electronic
T1 A multicenter study of antimicrobial resistance of clinical strains of pneumococci in Kyrgyzstan
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA2616
DO 10.1183/13993003.congress-2016.PA2616
VO 48
IS suppl 60
A1 Berik Emilov
A1 Mairam Alybaeva
A1 Ainura Ergeshova
A1 Bermet Estebesova
A1 Barton Smith
A1 Talant Sooronbaev
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA2616.abstract
AB Background: The highest death rates from respiratory infections, including pneumonia. One of the serious problem is the selection of antibiotic therapy for respiratory infections due to the absence of any research on antibiotic resistance of bacteriaObjective: To investigate the structure of antimicrobial resistance of clinical strains of pneumococcus in Kyrgyzstan.Materials and methods: This is a prospective, multicenter study involving 4 major centers of Kyrgyzstan. Biological Materials were collected from patients with community-acquired pneumonia, acute exacerbations of COPD, acute sinusitis and acute otitis media. Collection and delivery is carried out according to the standard requirements. Patients received antibiotic therapy within the last month, and any surgery was excluded from the study. Determination of antibiotic sensitivity was performed by disk diffusion method.Results: From examined 52 biological samples were allocated 19 Streptococcus pneumoniae. Other isolated microorganisms were: Escherichia coli, Proteus vulgaris, Pseudomonas aëruginosa, Haemophilus influenzae, Klebsiella pneumoniae. Preliminary results of the study showed a trend of high resistant pneumococci to amoxicillin clavulanate (63.1%), erythromycin (68.4%), cefazolin (100%), ceftriaxone (47.3%), cefuroxime(63.1%), ceftazidime (94.7%), cefotaxime (73.6%), norfloxacin (42.1%), to levofloxacin (31.5%), amikacin (78.9%), gentamicin (84.2%), ertapenem (47.3%), fosfomycin (94.7%), clindamycin (31.5%), trimethoprim (84.2%).Conclusions: The preliminary results showed a high resistance of Streptococcus Pneumoniae to commonly and routinely used antibiotics.