TY - JOUR T1 - Pulmonary hypertension in hypersensitivity pneumonitis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA2450 VL - 48 IS - suppl 60 SP - PA2450 AU - Adrienn Tornyos AU - Martin Trinker AU - Vasile Foris AU - Susanne Pfeiffer AU - Balazs Odler AU - Philipp Douschan AU - Alexander Avian AU - Andrea Olschewski AU - Gabor Kovacs AU - Horst Olschewski Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA2450.abstract N2 - Background and aims: Hypersensitivity Pneumonitis (HP) is an interstitial lung disease which may lead to lung fibrosis and pulmonary hypertension (PH). According to recent data, PH may be a frequent complication of HP but its exact prevalence is not fully explored. We aimed to assess the prevalence of increased pulmonary arterial pressure (PAP) and right ventricular strain (RVS) in HP patients.Methods: HP patients undergoing rehabilitation between 1997 and 2015 at the Rehabilitation Clinic Bad Gleichenberg were enrolled in this single centre retrospective study. Demographic data, comorbidities and therapy as well as echocardiography (echo) and electrocardiography (ECG) were evaluated. The primary endpoint of the study was the frequency of elevated PAP and RVS in the echo and right axis deviation (RAD) in ECG. Association analysis with all-cause mortality was performed by Kaplan- Meier and Cox regression analysis.Results: 423 patients (283 male, 140 female) were enrolled in the study (mean age: 53.4±10.1). During the follow up period (median 7.0 years) 5.2 % of the patients died. 165 patients underwent echo and systolic PAP (SPAP) was assessed in 84 cases. Mean SPAP was 42.1±12.7 mmHg and 50 patients had SPAP>35 mmHg. 94 patients had evidence of RVS by echo. Patients presenting with both SPAP>35 mmHg and RVS (n=42) had worse survival (p=0.02). In patients with ECG (n=419), RAD was present in 32 (7.6%) subjects, and was strongly associated with worse survival (p<0.001).Conclusion: Based on our study, elevated PAP values and/or RVS are present in a considerable proportion of HP patients and associated with a poor prognosis. Further investigation of the pulmonary hemodynamic in HP patients is warranted. ER -