RT Journal Article
SR Electronic
T1 Computerized auscultation for the diagnosis of COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA4439
DO 10.1183/13993003.congress-2016.PA4439
VO 48
IS suppl 60
A1 Cristina Jácome
A1 Ana Machado
A1 Alda Marques
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA4439.abstract
AB Spirometry, the gold standard for COPD diagnosis, results in a substantial proportion of undiagnosed subjects with mild airflow obstruction. Optimal screening methods for COPD are still to be identified. Computerized auscultation of respiratory sounds (RS) provide information on the respiratory system by nearly universally means. RS may thus contribute for early diagnosing COPD, but differences between healthy subjects and subjects with mild COPD have not been explored.This study compared RS between healthy subjects and subjects with mild COPD.10 healthy subjects (65±7y; FEV1 100±15% pred) and 13 subjects with mild COPD (68±8y; FEV1 88±8% pred) participated. RS were recorded at posterior right chest using a stethoscope with a microphone in the main tube. Airflow was standardized (0.4-0.6l/s) with a pneumotachograph. Breathing phases were detected using airflow signals and RS with developed algorithms. Inferential statistics included independent t-tests, Mann-Whitney U-tests and simple logistic regressions.Subjects with mild COPD presented significantly more inspiratory crackles (OR=5.18[95%CI 1.2-21.4]) and higher intensity in expiratory normal RS (OR=2.5[95%CI 1.1-5.9]) than healthy subjects. InspirationHealthyMild COPDNo. Crackles0.8[0.6, 2.4]2[1.3, 3.9]*Wheeze occupation rate,%0[0, 0]0[0, 5.3]NRS mean intensity,dB8.2±1.18.7±1.6ExpirationNo. Crackles0.8[0.7, 1.5]2.4[1.2, 4.8]Wheeze occupation rate,%0[0, 0.7]0[0, 4.7]NRS mean intensity,dB7.9±1.09.7±1.7*Data are presented as median[interquartile range] or mean±SD, *p<0.05RS parametersComputerized auscultation at posterior chest can aid in COPD diagnosis, this can be especially valuable in primary care or resource-constrained settings.