RT Journal Article
SR Electronic
T1 Central venous oxygen saturation as predictor of a successful spontaneous breathing trial outcome in mechanically ventilated patients
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP PA3568
DO 10.1183/13993003.congress-2016.PA3568
VO 48
IS suppl 60
A1 Ioannis Georgakas
A1 Afroditi Boutou
A1 Georgia Pitsiou
A1 Ioannis Kioumis
A1 Milly Bitzani
A1 Apostolos Sgouradis
A1 Paraskevi Argyropoulou
A1 Ioannis Stanopoulos
YR 2016
UL http://erj.ersjournals.com/content/48/suppl_60/PA3568.abstract
AB Rationale: Weaning from mechanical ventilation is a key element in the care of the critically ill patient and spontaneous breathing trial (SBT) is a crucial step in this procedure. This study aimed to evaluate the diagnostic accuracy of central venous oxygen saturation (ScvO2), a marker of tissue oxygenation, as a potential predictor of successful SBT.Methods: This is a nested case-control study. A consecutive population of patients who were mechanically ventilated for ≥48h and fulfilled the initial criteria of readiness to wean, according to guidelines1, constituted the study population. All patients attempted a SBT. Patients were categorized to cases (SBT success) and controls (SBT failure), based on a combination of specific criteria1 which indicated whether SBT was successful or not. Binary logistic regression analysis was utilized to indicate independent predictors of SBT success and ROC curve was used to demonstrate diagnostic accuracy of indices.Results: 77 patients (64.8±16.3 years; 62.3% male) constituted the study population. SBT was successful in 63.6% of them. SvO2 predicted SBT success (OR: 1.122; 95% CI:1.005-1.257) independently of age, hemoglobin concentration, arterial oxygen saturation (SaO2), arterial oxygen partial pressure (PaO2) and respiratory rate to tidal volume ratio. Diagnostic accuracy for ScvO2 alone (ROC area=0.685) was superior of that of either SaO2 (0.625) or PaO2 (0.619) alone to predict SBT success.Conclusion: ScvO2 seems to be a useful parameter which could further facilitate the accurate categorization among those patients who pass or fail the SBT.1 Boles J.M., et al. Eur Respir J 2007; 29: 1033–1056.