TY - JOUR T1 - Impaired control of gait in patients with severe obstructive sleep apnea is reversed by continuous positive airway pressure treatment JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2016.PA5033 VL - 48 IS - suppl 60 SP - PA5033 AU - Sébastien Baillieul AU - Bernard Wuyam AU - Mathieu Marillier AU - Dominic Perennou AU - Jean-Louis Pepin AU - Samuel Verges Y1 - 2016/09/01 UR - http://erj.ersjournals.com/content/48/suppl_60/PA5033.abstract N2 - Obstructive sleep apnea (OSA) is now widely seen as a major public health issue with many widespread societal consequences including mood, behavioral and cognitive deficits that impair work performance and productivity. In two recent uncontrolled studies, OSA has been associated with gait impairments, which seemed to be improved after an 8-week continuous positive airway pressure (CPAP) treatment. The present controlled study investigated the impact of an 8-week CPAP treatment on single and dual task gait performances and postural control in OSA patients.Twelve OSA patients (age=57.2±8.9 years, BMI=27.4±3.1 kg.m-2, AHI=46.3±11.7, Epworth sleepiness scale=10±5) and 10 healthy matched subjects were included. Kinetic postural parameters on a stable and moving platform and spatio-temporal gait parameters were recorded under single and dual task conditions using a visuo-verbal cognitive task (Stroop test).Higher stride time variability (STV) (3.1±1.1% vs 2.1±0.5%, p=0.02) and higher mean surface of center of pressure on stable plan under single task condition (131.2±79.8mm² vs 66.9±21.9mm², p=0.02) were measured in OSAS patients compared to controls. After CPAP treatment, STV was improved (2.4±0.5%, p=0.005) and no longer different compared to controls (p=0.32). Cognitive performance of OSA patients under dual task was impaired at baseline and improved under treatment.The present study shows that severe non-obese OSA patients have impaired gait control and suggests their cognitive origin, which are reversed after 8 weeks of CPAP treatment. The cerebral and neuromuscular substrates of these gait control impairments need to be further elucidated. ER -